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The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may cause a rise in methadone plasma concentrations, which could lead to potentially lethal respiratory despair. On top of that, discontinuation of concomitantly utilised cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also result in a rise i

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